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[Role of oncogenic G-proteins in development of endocrine neoplasms]
1I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg.
Voprosy Onkologii
|June 1, 2001
Abstract:
New data available in the literature on the role of oncogenic heterotrimeric GTP-proteins (G-proteins) in endocrine tissue carcinogenesis have been analyzed. A conclusion is made that stimulatory G-proteins coded by the gsp-oncogene are a major factor of the development of some pituitary and thyroid tumors. However, the role of the other oncogenic G-proteins in tumorigenesis remains unclear.