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Clinicopathological characteristics of left ventricular myocardium with transient asynergy: report of three cases

K Chida1, T Taniguchi, S Maeda

  • 1Division of Cardiology, Tokyo Metropolitan Geriatric Hospital, Japan.

Japanese Heart Journal
|June 1, 2001
PubMed

Insights

Transient left ventricular asynergy following acute ischemic events often involves normal heart muscle or minor subendocardial damage. This finding suggests the heart muscle can recover significantly after such insults.

Area of Science:

  • Cardiology
  • Pathology

Background:

  • Acute ischemic insults can cause transient left ventricular asynergy.
  • Understanding the underlying histopathologic substrates is crucial for patient management.

Purpose of the Study:

  • To investigate the histopathologic basis of transient left ventricular asynergy in patients experiencing acute ischemic events.
  • To correlate clinical and echocardiographic findings with myocardial pathology.

Main Methods:

  • Retrospective analysis of three patients with prolonged chest pain, new Q waves, and ST segment elevation.
  • Echocardiography to assess left ventricular function and structure.
  • Histopathologic examination of myocardial tissue.

Main Results:

  • Echocardiograms revealed severe hypokinesis/akinesis and thinning in the anteroseptal and apical regions.
  • Clinical and echocardiographic abnormalities resolved within weeks.
  • Histopathology showed either normal myocardium, small subendocardial scars, or scattered necrotic myocytes in the jeopardized regions.

Conclusions:

  • Transient left ventricular asynergy post-ischemia is often associated with normal myocardium or minimal subendocardial lesions.
  • The myocardium in these cases demonstrates significant recovery potential.

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