HL-A antigens and thyrotoxicosis

HL-A phenotypes were determined in 60 patients with primary thyrotoxicosis and in 60 age-sex matched controls living in the same region in order to establish the frequencies of ten HL-A antigens in the two populations. HL-A1 was present in 28 patients and 18 controls (X2 equals 2;86, P greater than 0,05); HL-A13 was present in eigth patients and only one control (X2 equals 4.32, 0.05 greater than P greater than 0.025). These findings suggest that HL-A phenotypes may be of value in studies on the aetiology of primary thyrotoxicosis. The statistical significance of these results is discussed as these findings may be due to chance deviations.