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Cryoglobulinemia associated with Purtscher-like retinopathy
J P Myers1, A M Di Bisceglie, E S Mann
1Department of Ophthalmology, Saint Louis University Health Sciences Center, St. Louis, Missouri, USA.
American Journal of Ophthalmology
|June 1, 2001
Summary
A case report highlights Purtscher-like retinopathy in a patient with chronic hepatitis C-associated cryoglobulinemia. This emphasizes the importance of considering cryoglobulinemia in diagnosing such visual disturbances.
Area of Science:
- Ophthalmology
- Nephrology
- Rheumatology
Background:
- Chronic hepatitis C infection is a common cause of cryoglobulinemia.
- Cryoglobulinemia can manifest with various systemic and ocular complications.
Observation:
- A 44-year-old man with chronic hepatitis C presented with sudden vision loss and abdominal pain.
- Ocular examination revealed Purtscher-like retinopathy, characterized by cotton-wool spots and retinal whitening.
- Systemic workup showed elevated rheumatoid factor, hypertension, and acute renal insufficiency.
Findings:
- Renal biopsy confirmed type II mixed cryoglobulinemia with immunoglobulin and complement deposition.
- The patient's presentation suggests a link between hepatitis C, cryoglobulinemia, and Purtscher-like retinopathy.
Implications:
- Clinicians should include cryoglobulinemia in the differential diagnosis for Purtscher-like retinopathy, especially in patients with hepatitis C.
- Early recognition and management of cryoglobulinemia may prevent severe visual and renal complications.
