The protein kinase activity modulation sites: mechanisms for cellular regulation - targets for therapeutic intervention

The low frequency of clinical resistance to PDGFR inhibitors in myeloid neoplasms with abnormalities of PDGFRA might be related to the limited repertoire of possible PDGFRA kinase domain mutations in vitro.

Oncogene·2010

High thermostability and lack of cooperative DNA binding distinguish the p63 core domain from the homologous tumor suppressor p53.

The Journal of biological chemistry·2001

The interaction of insulin-like growth factor-I with the N-terminal domain of IGFBP-5.

The EMBO journal·2001

The 1.8-A crystal structure of a matrix metalloproteinase 8-barbiturate inhibitor complex reveals a previously unobserved mechanism for collagenase substrate recognition.

The Journal of biological chemistry·2001

Analysis of protein phosphorylation by a combination of elastase digestion and neutral loss tandem mass spectrometry.

Analytical chemistry·2001

The extracellular human melanoma inhibitory activity (MIA) protein adopts an SH3 domain-like fold.

The EMBO journal·2001

RAS oncogene-mediated deregulation of the transcriptome: from molecular signature to function.

Advances in enzyme regulation·2010

Temporal and functional analysis of DNA replicated in early S phase.

Advances in enzyme regulation·2010

Genetic ablation of S6-kinase does not prevent processing of SREBP1.

Advances in enzyme regulation·2010

Sphingosine kinase localization in the control of sphingolipid metabolism.

Advances in enzyme regulation·2010

Inositol and its derivatives: their evolution and functions.

Advances in enzyme regulation·2010

Receptor tyrosine kinase signaling--a proteomic perspective.

Advances in enzyme regulation·2010

Zerumbone combined with antimicrobial photodynamic inactivation reduces growth of Candida albicans biofilms and modulates virulence gene expression.

Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology·2026

Inhibiting glioma cell invasion by sequential photo-sonodynamic therapy.

Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology·2026

Vismodegib-loaded ufasomes inhaler for treatment of non-small cell lung cancer.

Naunyn-Schmiedeberg's archives of pharmacology·2026

A 177Lu-Labeled Circular Bivalent Aptamer for PTK7-Targeting Radionuclide Therapy in Ovarian Cancer and Orthotopic Hepatoblastoma.

Journal of medicinal chemistry·2026

Small-Molecule Activators of PRMT1: Discovery, SAR Analyses, and Proapoptotic Effects in Pancreatic Cancer Cells.

Journal of medicinal chemistry·2026

Discovery of Highly Efficacious CRBN-Based KRAS Degraders Targeting Cancers with KRAS G12D and G12V Mutations.

Journal of medicinal chemistry·2026

Related Experiment Videos

The protein kinase activity modulation sites: mechanisms for cellular regulation - targets for therapeutic

Related Concept Videos

The low frequency of clinical resistance to PDGFR inhibitors in myeloid neoplasms with abnormalities of PDGFRA might be related to the limited repertoire of possible PDGFRA kinase domain mutations in vitro.

High thermostability and lack of cooperative DNA binding distinguish the p63 core domain from the homologous tumor suppressor p53.

The interaction of insulin-like growth factor-I with the N-terminal domain of IGFBP-5.

The 1.8-A crystal structure of a matrix metalloproteinase 8-barbiturate inhibitor complex reveals a previously unobserved mechanism for collagenase substrate recognition.

Analysis of protein phosphorylation by a combination of elastase digestion and neutral loss tandem mass spectrometry.

The extracellular human melanoma inhibitory activity (MIA) protein adopts an SH3 domain-like fold.

RAS oncogene-mediated deregulation of the transcriptome: from molecular signature to function.

Temporal and functional analysis of DNA replicated in early S phase.

Genetic ablation of S6-kinase does not prevent processing of SREBP1.

Sphingosine kinase localization in the control of sphingolipid metabolism.

Inositol and its derivatives: their evolution and functions.

Receptor tyrosine kinase signaling--a proteomic perspective.

Zerumbone combined with antimicrobial photodynamic inactivation reduces growth of Candida albicans biofilms and modulates virulence gene expression.

Inhibiting glioma cell invasion by sequential photo-sonodynamic therapy.

Vismodegib-loaded ufasomes inhaler for treatment of non-small cell lung cancer.

A 177Lu-Labeled Circular Bivalent Aptamer for PTK7-Targeting Radionuclide Therapy in Ovarian Cancer and Orthotopic Hepatoblastoma.

Small-Molecule Activators of PRMT1: Discovery, SAR Analyses, and Proapoptotic Effects in Pancreatic Cancer Cells.

Discovery of Highly Efficacious CRBN-Based KRAS Degraders Targeting Cancers with KRAS G12D and G12V Mutations.

Related Experiment Videos

The protein kinase activity modulation sites: mechanisms for cellular regulation - targets for therapeutic...

Related Concept Videos

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The protein kinase activity modulation sites: mechanisms for cellular regulation - targets for therapeutic