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Updated: Aug 8, 2026

Quantitative Analysis of Chromatin Proteomes in Disease
Published on: December 28, 2012
Compartmentalization of regulatory proteins in the cell nucleus
M J Hendzel1, M J Kruhlak, N A MacLean
1Department of Oncology and Cross Cancer Institute, Faculty of Medicine and Dentistry, University of Alberta, 11560 University Ave., Alta, T6G 1Z2, Edmonton, Canada. michaelh@cancerboard.ab.ca
Abstract:
The cell nucleus is increasingly recognized as a spatially organized structure. In this review, the nature and controversies associated with nuclear compartmentalization are discussed. The relationship between nuclear structure and organization of proteins involved in the regulation of RNA polymerase II-transcribed genes is then discussed. Finally, very recent data on the mobility of these proteins within the cell nucleus is considered and their implications for regulation through compartmentalization of proteins and genomic DNA are discussed.
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