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[Angiotensin-converting enzyme and its physiological role]
1Orekhovich Institute of Biomedical Chemistry, RAMS, Pogodinskaya St. 10, 119832 Moscow, Russia.
Voprosy Meditsinskoi Khimii
|June 2, 2001
Summary
Angiotensin-converting enzyme (ACE) regulates blood pressure and cell proliferation. Its structure, gene variations, and domain-specific actions influence physiological roles and disease risk.
Area of Science:
- Biochemistry and Molecular Biology
- Physiology
- Genetics
Context:
- Angiotensin-converting enzyme (ACE) is crucial for blood pressure regulation.
- ACE also influences other physiological processes, including cell proliferation.
- Understanding ACE's diverse functions requires examining its structure and genetic variations.
Purpose:
- To discuss the structural peculiarities of ACE.
- To explore the relationship between ACE gene polymorphism and its physiological functions.
- To highlight the distinct catalytic properties of ACE's N- and C-domains.
Summary:
- ACE comprises two homologous domains (N- and C-domains) with differing catalytic properties, suggesting physiological importance.
- Specific endogenous substrates for each domain and active single-domain ACE forms have been identified.
- ACE gene polymorphism is linked to plasma ACE levels and increased risk of cardiovascular and renal diseases.
Impact:
- Reveals the functional significance of ACE's structural domains.
- Connects ACE gene variations to disease susceptibility.
- Provides insights into ACE's multifaceted roles beyond blood pressure control.