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Brain oedema in secretory meningiomas
R Buhl1, H H Hugo, H M Mehdorn
1Department of Neurosurgery, University of Kiel, Germany.
Summary
Secretory meningiomas frequently cause brain swelling (oedema), affecting 82% of patients. These rare tumors, predominantly in females, showed good outcomes after surgery, suggesting hormonal factors may influence oedema.
Area of Science:
- Neuro-oncology
- Pathology
- Neurosurgery
Background:
- Brain oedema is common in intracranial meningiomas (50-66%).
- Potential causes include tumor location, vascularity, angiogenic factors, and histology.
- The etiology of meningioma-associated oedema is likely multifactorial.
Purpose of the Study:
- To investigate the occurrence and characteristics of brain oedema in secretory meningiomas.
- To explore potential contributing factors, including patient demographics and tumor location.
- To assess the clinical outcomes following surgical management of these rare tumors.
Main Methods:
- Retrospective analysis of 11 patients diagnosed with secretory meningiomas.
- Clinical data review, including imaging, surgical outcomes, and follow-up.
- Correlation of brain oedema presence with tumor characteristics and patient demographics.
Main Results:
- Brain oedema was present in 82% of the 11 patients with secretory meningiomas.
- Tumors were predominantly located at the frontal convexity and sphenoid ridge.
- All 11 patients were female, suggesting a potential role for hormonal factors.
Conclusions:
- Secretory meningiomas are strongly associated with significant peritumoural brain oedema.
- Tumor location and potential hormonal influences may contribute to oedema development.
- Surgical resection resulted in good postoperative outcomes with no recurrences during follow-up.