Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

The sharing of cDNA microarray data.

¹Gerontology Research Center, Room 4-D16, 5600 Nathan Shock Drive, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA. beckerk@grc.nia.nih.gov

Nature Reviews. Neuroscience

|June 5, 2001

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Hepatitis C virus upregulates B-cell receptor signaling: a novel mechanism for HCV-associated B-cell lymphoproliferative disorders.

Oncogene·2015

Same author

Postnatal TLR2 activation impairs learning and memory in adulthood.

Brain, behavior, and immunity·2015

Same author

Senescence induced by RECQL4 dysfunction contributes to Rothmund-Thomson syndrome features in mice.

Cell death & disease·2014

Same author

CAPC negatively regulates NF-κB activation and suppresses tumor growth and metastasis.

Oncogene·2011

Same author

The brain expression of genes involved in inflammatory response, the ribosome, and learning and memory is altered by centrally injected lipopolysaccharide in mice.

The pharmacogenomics journal·2008

Same author

Post-transcriptional gene regulation by HuR promotes a more tumorigenic phenotype.

Oncogene·2008

Same journal

Brain-spleen axis regulates learned fear.

Nature reviews. Neuroscience·2026

Same journal

Acetylcholine: a candidate substrate for hippocampal predictive learning?

Nature reviews. Neuroscience·2026

Same journal

Astrocytes viewed through the lens of their proteomes and subproteomes.

Nature reviews. Neuroscience·2026

Same journal

m<sup>6</sup>A in RNA: a key regulator of brain development, function and disease.

Nature reviews. Neuroscience·2026

Same journal

Non-invasive deep-brain neuromodulation by transcranial radio frequency stimulation.

Nature reviews. Neuroscience·2026

Same journal

Heading into the wild: setting the course to natural neuroscience.

Nature reviews. Neuroscience·2026

See all related articles

Sharing cDNA microarray data is of great interest, but challenges with format, quality, and validation must be addressed. Resolving these issues is crucial for integrating this valuable molecular data into broader databases.

Area of Science:

Molecular Biology
Bioinformatics
Data Science

Background:

Early microarray development focused on technological aspects.
Current research emphasizes microarray data analysis and sharing.
Interest in sharing cDNA microarray data is high within the scientific community.

Purpose of the Study:

To highlight the shift in focus from microarray technology to data analysis and sharing.
To identify key challenges hindering the integration of cDNA microarray data into molecular databases.

Main Methods:

Literature review and synthesis of current discussions on microarray data.
Analysis of issues pertaining to data format, quality control, and validation.

Main Results:

Related Experiment Videos

The primary focus has evolved from microarray technology to data analysis and sharing.
Significant obstacles exist in standardizing data format, ensuring data quality, and validating results.
These issues impede the seamless integration of cDNA microarray data with other molecular databases.

Conclusions:

Effective integration of cDNA microarray data requires resolution of format, quality, and validation challenges.
Standardization efforts are necessary to facilitate data sharing and enhance the utility of molecular databases.