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Cystic fibrosis in three children with bronchopulmonary dysplasia

N L Holmgren1, A Faro, M I Gondor

  • 1Division of Pulmonology, Department of Pediatrics, University of Miami, Miami, Florida 32610, USA.

Pediatric Pulmonology
|June 5, 2001
PubMed

Insights

Diagnosing cystic fibrosis (CF) in infants with bronchopulmonary dysplasia (BPD) is challenging due to overlapping symptoms. Early CF detection in BPD patients is crucial for better lung and nutritional outcomes.

Area of Science:

  • Pediatric Pulmonology
  • Neonatology
  • Medical Genetics

Background:

  • Cystic Fibrosis (CF) and Bronchopulmonary Dysplasia (BPD) are leading causes of pediatric chronic lung disease.
  • Both conditions present with overlapping symptoms like recurrent respiratory issues and failure to thrive, complicating diagnosis in infants.
  • Early diagnosis of CF is critical for improving lung health and nutritional status in children.

Observation:

  • This study details three infants diagnosed with both BPD and CF.
  • These infants exhibited shared symptoms including respiratory distress, prolonged oxygen dependency, and persistent failure to gain weight despite pancreatic enzyme therapy.
  • Metabolic alkalosis was noted in two of the three infants.

Findings:

  • The co-occurrence of BPD and CF presents diagnostic challenges due to similar clinical presentations.
  • Infants with both conditions may require a high index of suspicion for timely CF diagnosis.
  • Pancreatic enzyme supplementation alone may not resolve failure to thrive in CF patients with BPD.

Implications:

  • Early and accurate diagnosis of CF in infants with BPD is essential for initiating appropriate management.
  • Prompt intervention can potentially mitigate long-term pulmonary and nutritional complications in these vulnerable children.
  • This highlights the need for increased clinical awareness and diagnostic vigilance for CF in infants presenting with BPD symptoms.

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