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Images of Action Potential Propagation in Heart
1Department of Cell Biology and Physiology at the University of Pittsburgh School of Medicine, 3500 Terrace Street, Pittsburgh, PA 15261.
Abstract:
Activation and repolarization across mammalian hearts follow complex three-dimensional pathways that are governed by fiber structure, intercellular coupling, and action potentials (APs) with spatially heterogeneous properties. Voltage-sensitive dyes and imaging techniques offer new insights on how spatiotemporal heterogeneities of APs govern propagation, repolarization, and AV node conduction and help us visualize arrhythmias with previously unattainable details.