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Updated: Oct 2, 2026

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
Published on: February 6, 2015
Potentiation of antitumor effects of cisplatin by tumor necrosis factor-beta
G M Sysoeva1, V A Fadina, N A Popova
1Research Construction-and-Technology Institute of Biologically Active Substances, Vektor State Research Center, Novosibirsk, Siberia, Russia. nb@online.sinor.ru
Abstract:
Recombinant tumor necrosis factor-beta potentiated the inhibitory effect of cisplatin on intramuscularly transplanted GA-1 tumor and liver metastasis in mice. The antitumor effect was related to cytotoxic and cytostatic activities of the test preparations rather than to initiation of apoptosis.
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