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Synthesis of polyamine derivatives having non-hypotensive Ca2 +-permeable AMPA receptor antagonist activity
Y Yoneda1, S Kawajiri, A Hasegawa
1Medicinal Chemistry Research Laboratory, Daiichi Pharmaceutical Co, Ltd, Tokyo, Japan. yonedL0z@daiichipharm.co.jp
Bioorganic & Medicinal Chemistry Letters
|June 8, 2001
Abstract:
In order to obtain non-hypotensive and Ca2+-permeable AMPA receptor antagonists, we have synthesized a series of 1,4-bis(4-piperidinylmethyl)diaminobutanes. Compounds 13b, c, f had desirable properties.