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Reversal of lipopolysaccharide-analog-induced antibody suppression by anti-transforming growth factor beta and
M J Odean1, A G Johnson, M Mohrman
1Department of Medical Microbiology and Immunology, University of Minnesota, Duluth 55812, USA.
Abstract:
Monophosphoryl lipid A and a synthetic, nontoxic monosaccharide analog of lipid A, termed GLA 60, both strongly suppressed antibody production when administered 1 to 2 days prior to antigen. Evidence is presented that this suppression was mediated by two cytokines, prostaglandin E and transforming growth factor beta, because it was reversed by multiple injections of the cyclooxygenase inhibitor indomethacin and by in vitro addition of antibody to transforming growth factor beta.
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