Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Anal Fissure.

M Jonas1, J H Scholefield

  • 1Section of Surgery, University Hospital, Queen's Medical Centre, Nottingham, United Kingdom.

Gastroenterology Clinics of North America
|June 8, 2001
PubMed
Summary
This summary is machine-generated.

Topical treatments and botulinum toxin injections offer effective alternatives to surgery for anal fissures, healing most cases and avoiding surgical risks like incontinence. Novel pharmacologic agents may also treat resistant fissures.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical practice guidelines for the management of fever and neutropenia in South African children and adolescents with cancer.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2026
Same author

Scaling and networking a modular photonic quantum computer.

Nature·2025
Same author

Psychological impact of medical evacuation for ICU saturation in Covid-19-related ARDS patients.

Journal of psychiatric research·2024
Same author

Broadband, millimeter-wave antireflection coatings for large-format, cryogenic aluminum oxide optics.

Applied optics·2020
Same author

Influence of Sudden Cardiac Arrest in Deceased Kidney Donors on Organ Function After Transplantation.

Transplantation proceedings·2018
Same author

[Spontaneous reposition of a hip prosthesis after atraumatic dislocation].

Der Orthopade·2017
Same journal

Living Donor Intestinal and Liver Transplantation.

Gastroenterology clinics of North America·2026
Same journal

Living Abdominal Organ Donation: A Plan B That Saves Lives.

Gastroenterology clinics of North America·2026
Same journal

Long-Term Outcomes of Living Liver Donors.

Gastroenterology clinics of North America·2026
Same journal

Perioperative Management of Living Liver Donor Patients.

Gastroenterology clinics of North America·2026
Same journal

Living Donor Liver Transplantation for Colorectal Cancer Liver Metastasis.

Gastroenterology clinics of North America·2026
Same journal

Living Donor Liver Graft in Adult Populations: Donor Selection and Workup.

Gastroenterology clinics of North America·2026
See all related articles

Area of Science:

  • Gastroenterology
  • Colorectal Surgery

Background:

  • Anal fissures are common, causing significant morbidity in young adults.
  • Traditional lateral internal sphincterotomy carries a 30% risk of incontinence.

Purpose of the Study:

  • To review current and emerging treatments for anal fissures.
  • To compare the efficacy and risks of pharmacologic versus surgical interventions.

Main Methods:

  • Review of existing literature on anal fissure treatments.
  • Analysis of pharmacologic agents (e.g., GTN, botulinum toxin) and surgical options.

Main Results:

  • Pharmacologic agents achieve high healing rates, allowing many patients to avoid surgery.
  • Topical 0.2% glyceryl trinitrate (GTN) is a widely used first-line treatment.

Related Experiment Videos

  • Botulinum toxin shows promise but may be less tolerable than other methods.

    • Conclusions:

    • Pharmacologic sphincterotomy is a viable alternative to surgery for most anal fissures.
    • Novel agents may treat GTN-resistant fissures, avoiding surgical risks.
    • Surgery remains an option for refractory cases or those with elevated anal pressures.