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Cardiovascular effects caused by rapid administration of gadoversetamide injection in anesthetized dogs
J H Wible1, K P Galen, J K Wojdyla
1Mallinckrodt Inc. St. Louis, MO 63134, USA. jhwible@mkg.com
Rationale And Objectives:
This study assessed the cardiovascular effects of gadoversetamide and other gadolinium chelates administered at high rates of injection.
Methods:
Anesthetized beagles were instrumented to record the electrocardiogram and to measure arterial blood pressure. In part 1, each animal was injected with gadoversetamide at rates of 1.0, 3.0, and 10 mL/s. In part 2, each animal was injected with gadoversetamide, gadopentetate dimeglumine, gadodiamide, and gadoteridol at a dose of 0.6 mmol/kg delivered at a rate of 3.0 mL/s.
Results:
Intravenous administration of gadoversetamide caused transient decreases in both heart rate and blood pressure. The rate of injection did not affect the magnitude of the heart rate or blood pressure changes. Administration of gadoversetamide, gadopentetate dimeglumine, and gadodiamide elicited equivalent changes in cardiovascular function. Injection of gadoteridol caused a similar degree of hypotension, but the changes lasted longer.
Conclusions:
Rapid administration of gadoversetamide caused no potentiation in cardiovascular changes. Our data support the initiation of a clinical trial to demonstrate the safety of rapidly administering gadoversetamide with the use of a power injector.