Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Peripubertal paternal EtOH exposure.

N V Emanuele1, N LaPagli, J Steiner

  • 1Department of Medicine, Loyola University Medical Center, Maywood, IL 60153, USA. memanue@wpo.it.luc.edu

Endocrine
|June 8, 2001
PubMed
Summary

Paternal alcohol consumption during puberty reduces male rat fertility and litter size. This may be due to testicular oxidative injury, impacting germ cells and offspring development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Spent coffee ground characterization, pelletization test and emissions assessment in the combustion process.

Scientific reports·2021
Same author

Anisakis pegreffii impacts differentiation and function of human dendritic cells.

Parasite immunology·2018
Same author

Smad7 positively regulates keratinocyte proliferation in psoriasis.

The British journal of dermatology·2017
Same author

IgE sensitization to Anisakis pegreffii in Italy: Comparison of two methods for the diagnosis of allergic anisakiasis.

Parasite immunology·2017
Same author

Assessing the effectiveness of sustainable land management policies for combating desertification: A data mining approach.

Journal of environmental management·2016
Same author

Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth.

Oncogene·2014

Area of Science:

  • Reproductive biology
  • Toxicology
  • Developmental biology

Background:

  • Fetal alcohol syndrome is linked to maternal alcohol use during pregnancy.
  • Paternal alcohol exposure's impact on offspring is less understood.
  • Previous studies explored alcohol's effects on peripubertal males.

Purpose of the Study:

  • To investigate the effects of chronic alcohol (EtOH) feeding in peripubertal male rats on their reproductive capacity.
  • To examine the characteristics of offspring resulting from matings with alcohol-exposed fathers.
  • To explore potential mechanisms, including testicular oxidative stress, linking paternal alcohol exposure to reproductive outcomes.

Main Methods:

  • Male rats were fed alcohol for 2 months through puberty.

Related Experiment Videos

  • Reproductive success and litter characteristics were assessed after mating with EtOH-naive females.
  • Testicular oxidative stress markers (lipid peroxidation, protein oxidation, glutathione ratio) were measured.
  • Offspring growth, sex ratio, and hormone levels (IGF-1, leptin) were analyzed.

    • Main Results:

    • Alcohol-fed males showed reduced body weight but successfully mated.
    • Pregnancy rates decreased significantly (92% to 75%) in alcohol-exposed fathers.
    • Testicular oxidative injury was evident in alcohol-fed males.
    • Litter size was reduced by 46% (6.7 pups vs. 12.4-12.5 pups).
    • Offspring from exposed fathers had increased average weight and a higher male-to-female ratio.
    • Leptin levels were elevated in offspring of alcohol-exposed fathers.

    Conclusions:

    • Chronic alcohol exposure in peripubertal male rats impairs fecundity.
    • Testicular oxidative injury is a likely mediator of reduced fertility.
    • Paternal alcohol consumption can influence offspring characteristics, including growth and sex ratio.
    • Further research may explore germ cell apoptosis as a consequence.