Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Adult Stem Cells01:33

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously renew...
Embryonic Stem Cells00:58

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...
Satellite Stem Cells and Muscular Dystrophy01:21

Satellite Stem Cells and Muscular Dystrophy

Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...
Source And Potency Of Stem Cells01:27

Source And Potency Of Stem Cells

Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
Embryonic Stem Cells00:57

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evidence of hysteresis in propofol pharmacodynamics.

Anaesthesia·2017
Same author

G-CSF Regulates the Expression of mRNA for Collagen Type VI and Collagen VI Production in Human Bone Marrow Stromal Cells.

Hematology (Amsterdam, Netherlands)·2016
Same author

[Osteochodral lesion mouse model: an alternative for experimental work].

Revista espanola de cirugia ortopedica y traumatologia·2014
Same author

[Treatment of acute full-thickness chondral defects with high molecular weight hyaluronic acid; an experimental model].

Revista espanola de cirugia ortopedica y traumatologia·2014
Same author

Combination cell therapy for the treatment of acute myocardial infarction.

International journal of cardiology·2012
Same author

A real-time PCR-based strategy for the detection of Paenibacillus larvae vegetative cells and spores to improve the diagnosis and the screening of American foulbrood.

Letters in applied microbiology·2010

Related Experiment Video

Updated: Jul 12, 2026

Isolating Mesangiogenic Progenitor Cells (MPCs) from Human Bone Marrow
09:53

Isolating Mesangiogenic Progenitor Cells (MPCs) from Human Bone Marrow

Published on: July 15, 2016

Mesenchymal stem cells.

J J Minguell1, A Erices, P Conget

  • 1Unidad de Biología Celular, INTA, Universidad de Chile, Casilla 138, Santiago 11, Chile. jminguel@uec.inta.uchile.cl

Experimental Biology and Medicine (Maywood, N.J.)
|June 9, 2001
PubMed
Summary

Mesenchymal stem cells (MSCs) from bone marrow are versatile cells that can differentiate into various cell types. Further research is needed to ensure their safe and effective clinical use in cell and gene therapies.

Area of Science:

  • Stem Cell Biology
  • Regenerative Medicine
  • Cell Biology

Background:

  • Bone marrow stroma contains mesenchymal stem/progenitor cells (MSCs).
  • MSCs possess multipotential differentiation capacity.
  • These cells are easily isolated, cultured, and expanded ex vivo.

Purpose of the Study:

  • To review the biology of mesenchymal progenitors.
  • To discuss their characteristics, proliferative hierarchy, and clinical applications.
  • To highlight unresolved questions for safe clinical use.

Main Methods:

  • Review of ex vivo studies on bone marrow-derived MSCs.
  • Analysis of existing literature on MSC characteristics and behavior.
  • Discussion of mobilization, microenvironment, and clinical potential.

More Related Videos

Isolation and Identification of Mesenchymal Stem Cells Derived from Adipose Tissue of Sprague Dawley Rats
10:50

Isolation and Identification of Mesenchymal Stem Cells Derived from Adipose Tissue of Sprague Dawley Rats

Published on: April 7, 2023

Comparison of Two Representative Methods for Differentiation of Human Induced Pluripotent Stem Cells into Mesenchymal Stromal Cells
06:24

Comparison of Two Representative Methods for Differentiation of Human Induced Pluripotent Stem Cells into Mesenchymal Stromal Cells

Published on: October 20, 2023

Related Experiment Videos

Last Updated: Jul 12, 2026

Isolating Mesangiogenic Progenitor Cells (MPCs) from Human Bone Marrow
09:53

Isolating Mesangiogenic Progenitor Cells (MPCs) from Human Bone Marrow

Published on: July 15, 2016

Isolation and Identification of Mesenchymal Stem Cells Derived from Adipose Tissue of Sprague Dawley Rats
10:50

Isolation and Identification of Mesenchymal Stem Cells Derived from Adipose Tissue of Sprague Dawley Rats

Published on: April 7, 2023

Comparison of Two Representative Methods for Differentiation of Human Induced Pluripotent Stem Cells into Mesenchymal Stromal Cells
06:24

Comparison of Two Representative Methods for Differentiation of Human Induced Pluripotent Stem Cells into Mesenchymal Stromal Cells

Published on: October 20, 2023

Main Results:

  • MSCs can differentiate into osteoblasts, chondrocytes, adipocytes, and more.
  • Evidence supports a repertoire of uncommitted and committed progenitors.
  • A proliferative hierarchy model for MSCs is presented.

Conclusions:

  • MSCs are attractive therapeutic tools due to their multipotency and expandability.
  • Fundamental questions remain regarding their safe and effective clinical application.
  • Further research is crucial for advancing MSC-based cell and gene therapies.