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Related Experiment Videos

CD99 immunoreactivity in ependymoma.

Y L Choi1, J G Chi, Y L Suh

  • 1Department of Diagnostic Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Applied Immunohistochemistry & Molecular Morphology : AIMM
|June 9, 2001
PubMed
Summary
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CD99 protein expression, characterized by strong membranous staining and intracytoplasmic dots, is a reliable marker for identifying ependymoma. This pattern effectively distinguishes ependymomas from other central nervous system tumors with similar histology.

Area of Science:

  • Neuropathology
  • Immunohistochemistry
  • Oncology

Background:

  • CD99 expression is known in ependymal cells and ependymomas.
  • Previous studies had limited sample sizes and lacked detailed expression patterns.

Purpose of the Study:

  • To investigate CD99 immunoreactivity in ependymoma.
  • To evaluate CD99's utility in the differential diagnosis of central nervous system tumors.

Main Methods:

  • Immunohistochemical staining for CD99 was performed on 25 ependymomas.
  • CD99 expression patterns were compared between ependymomas and 63 non-ependymal tumors with similar histology.

Main Results:

  • All ependymomas exhibited strong, diffuse membranous CD99 expression with intracytoplasmic or intercellular dots (ICDs).

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  • Non-ependymal tumors showed variable and often incomplete CD99 staining, lacking the characteristic ICD pattern seen in ependymomas.

    • Conclusions:

    • The distinct CD99 expression pattern (diffuse strong membranous staining with ICDs) is a valuable diagnostic tool.
    • This characteristic pattern aids in differentiating ependymomas from histologically similar central nervous system neoplasms.