Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Self-expandable chitosan stent: design and preparation.

A Lauto1, M Ohebshalom, M Esposito

  • 1Center for Pediatric Urology and Minimal Invasive Urologic Surgery, Department of Urology, New York-Presbyterian Hospital-Weill Medical College of Cornell University, NY 10021, USA. a_lauto@hotmail.com

Biomaterials
|June 9, 2001
PubMed
Summary

Researchers developed a novel, self-expanding biocompatible stent from chitosan films for surgical use. This innovative stent design shows promise for relieving obstructions, demonstrating elasticity and successful implantation in rat models.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Trapped Between Fatigue and Feelings: How Paediatric OSAS Affects Physical Activity and Emotion Recognition.

European journal of paediatric dentistry·2026
Same author

Black Hole Spectroscopy and Tests of General Relativity with GW250114.

Physical review letters·2026
Same author

Search for Postinflationary QCD Axions with a Quantum-Limited Tunable Microwave Receiver.

Physical review letters·2025
Same author

Tirbanibulin 1% real-world use in 679 actinic keratoses patients during warm season (SUMM-AK study).

Journal of the European Academy of Dermatology and Venereology : JEADV·2025
Same author

GW250114: Testing Hawking's Area Law and the Kerr Nature of Black Holes.

Physical review letters·2025
Same author

Effectiveness, speed of action and safety of brodalumab in elderly psoriasis patients: a multicenter real-world study - IL PSO (Italian Landscape Psoriasis).

The Journal of dermatological treatment·2025

Area of Science:

  • Biomaterials Science
  • Surgical Device Engineering
  • Regenerative Medicine

Background:

  • Stents are crucial medical devices for alleviating pathological obstructions during surgical procedures.
  • Current stent technologies face challenges regarding biocompatibility and self-expansion mechanisms.
  • Developing novel stent materials and designs is essential for improving surgical outcomes.

Purpose of the Study:

  • To design and fabricate a biocompatible stent with an integrated self-expandable mechanism.
  • To evaluate the mechanical properties and in vivo performance of the novel stent.
  • To explore the potential of chitosan-based materials for stent applications.

Main Methods:

  • Thin films of deacetylated chitosan were prepared and characterized for mechanical properties (Young's modulus).

Related Experiment Videos

  • Chitosan films were manufactured into helical stents (0.5 mm diameter, 4 mm length).
  • Stents were implanted into the vas deferens of wistar rats, with anastomosis performed using laser soldering.

    • Main Results:

    • Chitosan films exhibited significant elasticity (maximum strain 105% ± 6%, Young's modulus 0.7655 ± 0.0288 MPa).
    • The fabricated stents demonstrated effective self-expansion due to stored elastic energy.
    • All implanted stents, except one, remained patent after 8 weeks, despite sperm granuloma formation.

    Conclusions:

    • A biocompatible, self-expandable stent with a helical design was successfully developed using chitosan.
    • The study validates chitosan as a suitable material for creating elastic and functional stents.
    • The proposed stent design offers a promising solution for relieving obstructions in various surgical applications.