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Role of T-bet in commitment of TH1 cells before IL-12-dependent selection

A C Mullen1, F A High, A S Hutchins

  • 1Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6160, USA.

Science (New York, N.Y.)
|June 9, 2001
PubMed
Summary

T-bet initiates helper T (TH) cell differentiation into TH1 cells by remodeling chromatin and inducing IL-12 receptor expression. Interleukin-12 (IL-12)/STAT4 then promotes TH1 cell survival and sustained interferon-gamma (IFN-gamma) production.

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