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Updated: Oct 7, 2026
In Vitro Assay of Bacterial Adhesion onto Mammalian Epithelial Cells
Published on: May 16, 2011
Functional study of antibodies against a fibrogenin-binding protein in Staphylococcus epidermidis adherence to
1Division of Clinical Bacteriology, Department of Immunology, Pathology, and Microbiology, Huddinge University Hospital, Karolinska Institute, Stockholm, Sweden. lei.pei@impi.ki.se
Abstract:
Staphylococcus epidermidis is an important pathogen in foreign body-associated infections. In a previous study, we showed that a surface-located fibrinogen-binding protein, termed Fbe, from S. epidermidis mediated the bacterial adherence to fibrinogen-coated surfaces in vitro. In the present study, we demonstrate that antibodies against Fbe can block adherence of S. epidermidis to fibrinogen-coated catheters, subcutaneously implanted catheters from rats, and peripheral venous catheters from human patients.
