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Assessment of Child Anthropometry in a Large Epidemiologic Study
09:36

Assessment of Child Anthropometry in a Large Epidemiologic Study

Published on: February 2, 2017

Interrelationship between estimates of adiposity and body fat distribution with metabolic and hemostatic parameters

K Sudi1, S Gallistl, D Payerl

  • 1Institute for Sport Sciences, Karl-Franzens University, Graz, Austria.

Metabolism: Clinical and Experimental
|June 9, 2001
PubMed

Insights

Childhood obesity is linked to metabolic and clotting system issues. Upper body fat is a key factor in these metabolic and hemostatic changes in obese children.

Area of Science:

  • Pediatric Endocrinology
  • Hematology
  • Metabolic Syndrome

Background:

  • Childhood obesity is a growing concern, often associated with metabolic disturbances.
  • Obesity can lead to dysregulation of blood coagulation and fibrinolysis.
  • Understanding these links is crucial for preventing cardiovascular complications.

Purpose of the Study:

  • To investigate the relationship between metabolic and hemostatic parameters in obese children.
  • To explore how adiposity measures and fat distribution correlate with these parameters.

Main Methods:

  • Studied 34 obese boys and 57 obese girls, measuring body composition, waist/hip circumference, and subcutaneous adipose tissue (SAT) layers.
  • Assessed blood parameters including insulin, glucose, triglycerides, fibrinogen, plasminogen activator inhibitor-1 (PAI-1), and tissue-type plasminogen activator-antigen (tPA-Ag).
  • Utilized impedance for body composition, Lipometer for SAT, and factor analysis for SAT distribution.

Main Results:

  • Significant correlations found between adiposity measures, waist circumference, and metabolic parameters.
  • Fibrinogen associated with upper body subcutaneous fatness in boys; hemostatic parameters linked to overall adiposity in girls.
  • Regression analysis identified PAI-1, triglycerides, age, tPA-Ag, glucose, fibrinogen, and %FM as key determinants of hemostatic factors.

Conclusions:

  • Results support an interrelationship between metabolic and hemostatic parameters driven by increased adiposity in obese children.
  • Upper body subcutaneous fatness is a significant correlate of metabolic and hemostatic abnormalities.
  • Further research is needed to confirm the role of specific fat distribution patterns in the dysregulation of the hemostatic system in childhood obesity.

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