Related Experiment Video
Updated: Aug 17, 2026

Preparation of Quality Inositol Pyrophosphates
Published on: September 3, 2011
Synthesis of inositol glycan cyclic phosphates
C H Jaworek1, S Iacobucci, P Calias
1Department of Chemistry, Tufts University, Medford, MA 02155, USA.
Abstract:
An efficient synthesis of tri-, tetra-, and pentasaccharide cyclic phosphates 1-5, structurally related to natural inositol phosphate glycans, is reported. The title compounds were assembled by PhSeOTf-promoted glycosylation of the known glucosamine precursor, t-butyldimethylsilyl 2-azido-3,6-di-O-benzyl-2-deoxy-beta-D-glucopyranoside (8) with protected 1-methylthio mono-, di-, and trimannosides 7a-c, and, after conversion into glycosyl fluorides, Cp2ZrCl2- AgOTf-promoted glycosylation of differentially protected optically pure 1D-myo-inositol 11. The syntheses were completed by installing the cyclic phosphate moieties with methylpyridinium dichlorophosphate and finally, removal of all protecting groups by dissolving-metal reduction.
More Related Videos
09:01Extraction and Quantification of Soluble, Radiolabeled Inositol Polyphosphates from Different Plant Species using SAX-HPLC
Published on: June 26, 2020
09:22Absolute Quantitation of Inositol Pyrophosphates by Capillary Electrophoresis Electrospray Ionization Mass Spectrometry
Published on: August 13, 2021
Related Concept Videos
Phosphoinositides and PIPs
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...
Oligosaccharide Assembly
Multiple sugar molecules that may or may...
Synthesis of Phosphatidylcholine in the ER Membrane
The major components of all eukaryotic cell...
IP3/DAG Signaling Pathway
Biosynthesis of Polysaccharides
Biosynthesis of Nucleic Acids