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Updated: Aug 7, 2026

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
Published on: March 6, 2018
Crosstalk and considerations in endocrine disruptor research
B R Lackey1, S L Gray, D M Henricks
1Department of Animal and Veterinary Science, Endocrine Physiology Laboratory, Clemson University, Clemson, South Carolina, USA. blackey@clemson.edu
Abstract:
The presence of endocrine disrupting chemicals in the environment has prompted action on several fronts to assess the potential health risks of these compounds. To fully understand the mechanisms behind the observed endocrine disruption, crosstalk and other factors should be considered. In this article we will discuss how crosstalk modulates estrogen action in several common assays and how this and other considerations appear to have been overlooked. In addition, a paradigm shift from theoretical linear response pathways to interaction maps should aid in the understanding and analysis of endocrine disruption.
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