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Coordinate regulation of metabotropic glutamate receptors
S Alagarsamy1, S D Sorensen, P J Conn
11510 Clifton Road, Rollins Research Center Room 5160, Department of Pharmacology, Emory University, Atlanta, GA 30322, USA. salagar@emory.edu
Current Opinion in Neurobiology
|June 12, 2001
Abstract:
Recent studies aimed at identifying the mechanisms that regulate the signaling of metabotropic glutamate receptors (mGluRs) have revealed that both protein kinase and protein phosphatase activity are important in directly modulating mGluR function. The inter-relationship between phosphorylation and dephosphorylation of mGluRs seems to be an important determinant in regulating mGluR function and the subsequent neuromodulatory events elicited by activation of mGluRs.