Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cholinergic synaptic potentials in the supragranular layers of auditory cortex.

A E Bandrowski1, S L Moore, J H Ashe

  • 1Neuroscience Program, Department of Psychology, University of California, Riverside, California 92521, USA.

Synapse (New York, N.Y.)
|June 16, 2001
PubMed
Summary

Acetylcholine (ACh) influences auditory cortex receptive-field plasticity. This study identifies ACh-dependent depolarizing and hyperpolarizing potentials in rat auditory cortex neurons, revealing mechanisms for receptive-field modification.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Visualizing moiré ferroelectricity via plasmons and nano-photocurrent in graphene/twisted-WSe<sub>2</sub> structures.

Nature communications·2023
Same author

Negative refraction in hyperbolic hetero-bicrystals.

Science (New York, N.Y.)·2023
Same author

Nano-spectroscopy of excitons in atomically thin transition metal dichalcogenides.

Nature communications·2022
Same author

Nanoscale lattice dynamics in hexagonal boron nitride moiré superlattices.

Nature communications·2021
Same author

Flash glucose monitoring: Impact on markers of glycaemic control and patient-reported outcomes in individuals with type 1 diabetes mellitus in the real-world setting.

Diabetes research and clinical practice·2019
Same author

A GIS-based methodology for selecting stormwater disconnection opportunities.

Water science and technology : a journal of the International Association on Water Pollution Research·2012

Area of Science:

  • Neuroscience
  • Auditory Cortex Research
  • Synaptic Plasticity

Background:

  • Receptive-field plasticity in the auditory neocortex is crucial for learning and memory.
  • The precise mechanisms underlying auditory receptive-field changes, particularly involving acetylcholine (ACh), remain incompletely understood.

Purpose of the Study:

  • To investigate the role of acetylcholine (ACh) in auditory cortex receptive-field plasticity.
  • To characterize the specific electrical potentials involved in ACh-mediated receptive-field modifications.

Main Methods:

  • Whole-cell patch-clamp recordings from layer II/III pyramidal cells in rat auditory cortex slices.
  • Repetitive electrical stimulation (20-100 Hz) to evoke potentials.
  • Application of various receptor antagonists (glutamate, muscarinic ACh, GABA) to elucidate mechanisms.

Related Experiment Videos

  • Extracellular recordings to confirm cellular findings.

    • Main Results:

    • Repetitive stimulation elicited both depolarizing and hyperpolarizing potentials dependent on ACh.
    • Low-intensity stimulation favored hyperpolarizing responses (reversal potential -73 mV), mediated by ACh acting on GABAergic interneurons.
    • High-intensity stimulation favored depolarizing responses (reversal potential -35 mV), involving glutamate and muscarinic ACh receptors.

    Conclusions:

    • ACh plays a significant role in modulating auditory cortex receptive-field properties through distinct depolarizing and hyperpolarizing potentials.
    • These findings elucidate key cellular mechanisms underlying auditory plasticity and learning.
    • The differential activation of glutamate and GABAergic pathways by ACh highlights complex cortical processing.