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Differentiation in chronic myelogenous leukemia cell K562 by spongean sesterterpene
1Graduate School of Pharmaceutical Sciences, Osaka University, Yamada-oka 1-6, Osaka, Suita, 565-0871, Japan.
Abstract:
Scalarane-type sesterterpenes, PHC-1-PHC-7, which have been isolated from a marine sponge, increased hemoglobin production in human chronic myelogenous leukemia cell line K562 at the concentration of 0.1-5 microg/ml. PHC-1, the major constituent, induced the expression of glycophorin A and the enucleation for K562 cells. These sesterterpenes were found to induce erythroid differentiation in K562 cells. In addition, PHC-1 induced G1 arrest of the cell cycle of K562 cells.
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