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The relationship between HA-1 compatibility and the activation of helper T lymphocyte precursors
V Cukrová1, M Dobrovolná, M Vraná
1Institute of Hematology and Blood Transfusion, Prague, Czech Republic.
Immunobiology
|June 14, 2001
Abstract:
The relationship between the compatibility in minor histocompatibility HA-1 antigen and the activation of helper (IL-2 producing) T lymphocyte precursors in vitro was studied in the group of 17 HLA-A2 positive HLA identical siblings. Although the number of pairs studied is still small, no correlation has been found between HA-1 compatibility and helper T lymphocyte precursors activation. The results presented here could suggest the possibility that the HTLp assay does not have to be a relevant parameter for the detection of HA-1 mismatches in HLA identical siblings.