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Updated: Jul 30, 2026

Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram
Published on: November 27, 2016
Capillary electrochromatography of tricyclic antidepressants on strong cation exchangers with different pore sizes
A M Enlund1, R Isaksson, D Westerlund
1Uppsala University, Biomedical Center, Division of Analytical Pharmaceutical Chemistry, Sweden. anna-maria.enlund@farmkemi.uu.se
Abstract:
Four cation-exchange materials, possessing propanesulfonic acid ligands, for use in capillary electrochromatography were prepared from different commercially available 5-microm bare-silica particles ranging from 80 to 800 A in pore size. The performance of the materials was investigated at different compositions of the mobile phase (pH, ionic strength, and acetonitrile content) using tricyclic antidepressants and related quaternary ammonium analogues as test analytes. The wide-pore materials promoted pore flow, but this had no positive influence on the performance. The small-pore (highest surface area) particles gave, as could be expected, the best selectivity.
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