Related Experiment Video
Updated: Jun 30, 2026

Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy
Published on: September 17, 2017
Improved resolution in proton NMR spectroscopy of powdered solids
A Lesage1, L Duma, D Sakellariou
1Laboratoire de Stéréochimie et des Interactions Moléculaires, UMR-5532 CNRS/ENS, Ecole Normale Supérieure de Lyon, 69364 Lyon, France.
Abstract:
We present a new solid-state nuclear magnetic resonance experiment that yields, under CRAMPS decoupling conditions, a significant reduction in proton line widths for powdered organic solids. This experiment which relies on a constant-time acquisition of the proton transverse magnetization, removes the contribution of nonrefocusable broadening from the proton line widths. Although this new technique suffers from relatively low sensitivity, we demonstrate in this paper its feasibility on two model samples, L-alanine and the dipeptide Ala-Asp. In both cases a factor of between 2 and 3 in line width reduction is obtained for most of the proton resonances.
Related Concept Videos
Proton (¹H) NMR: Chemical Shift
Absorption signals of all the protium nuclei in a...
¹H NMR of Conformationally Flexible Molecules: Temporal Resolution
¹H NMR of Labile Protons: Temporal Resolution
The –OH proton in alcohols typically appears in the range of δ 2 to 5 ppm but can vary depending on the specific...
High-Resolution Mass Spectrometry (HRMS)
NMR Spectrometers: Resolution and Error Correction
NMR Spectroscopy Of Amines

