Related Experiment Videos
Unnatural natural products from the transannular cyclization of lathyrane diterpenes
G Appendino1, G C Tron, T Jarevång
1Università del Piemonte Orientale, DiSCAFF, Viale Ferrucci 33, 28100 Novara, Italy. appendin@pharm.unito.it
Organic Letters
|June 19, 2001
Abstract:
The potential of macrocyclic diterpenoids to afford natural product-like polycyclic compounds was demonstrated by the conversion of two lathyrane Euphorbia factors into a series of densely functionalized diterpenoids of unnatural skeletal type. Apparently, Nature is far from having fully exploited the built-in reactivity of these compounds to generate chemical diversity.