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Direct reductive amination of aldehydes and ketones using phenylsilane: catalysis by dibutyltin dichloride
1The R.W. Johnson Pharmaceutical Research Institute, San Diego, California 92121, USA. rapodaca@prius.jnj.com
Organic Letters
|June 19, 2001
Abstract:
A procedure for direct reductive amination of aldehydes and ketones was developed which uses phenylsilane as a stoichiometric reductant and dibutyltin dichloride as a catalyst. Suitable amines included anilines and dialkylamines but not monoalkylamines.