Synthesis of new cationic lipids from an unsaturated glycoside scaffold
J Herscovici1, M J Egron, A Quenot
1LCBBMC UMR 7001 CNRS-ENSCP-Aventis Gencell. ENSCP 11, rue Pierre et Marie Curie 75231 Paris Cedex France. herscovi@ext.jussieu.fr
Organic Letters
|June 19, 2001
Abstract:
[see structure]. We report the synthesis of new cationic lipids. These amphiphiles present a hydrophobic domain connected to a guanidinium entity by an unsaturated glycoside scaffold. The synthetic strategy using amide or acetal linkage led to various mono- and bicatenar derivatives. Investigation of their physicochemical properties indicated that these new compounds compact DNA.
