Related Experiment Videos
DNA-cation interactions: The major and minor grooves are flexible ionophores
1School of Chemistry and Biochemistry, Parker H Petit Institute of Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, Georgia 30332-0400, USA. hud@chemistry.gatech.edu
Current Opinion in Structural Biology
|June 19, 2001
Abstract:
Several crystallographic, solution-state and theoretical studies carried out this past year provide new support for the sequence-specific nature of monovalent and divalent cation coordination within the DNA major and minor grooves. Correlations observed between groove width and cation coordination indicate that the grooves are flexible and respond to cation binding.