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Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus
06:43

Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus

Published on: December 7, 2013

Severe atherosclerotic changes, including aortic occlusion, associated with hyperhomocysteinaemia and

P E Spronk1, E H Overbosch, N H Schut

  • 1Department of Internal Medicine, Kennemer Gasthuis (EG), Haarlem, The Netherlands. pspronk@wish.net

Annals of the Rheumatic Diseases
|June 19, 2001
PubMed

Insights

Severe atherosclerosis, including aortic occlusion, was observed in three patients with high anticardiolipin antibodies. This suggests antiphospholipid antibodies may play a role in atherosclerosis, especially with hyperhomocysteinaemia.

Area of Science:

  • Cardiovascular Medicine
  • Immunology
  • Metabolic Disorders

Background:

  • Atherosclerosis is a major cause of cardiovascular disease.
  • Hyperhomocysteinaemia is an emerging risk factor for atherosclerosis.
  • Antiphospholipid antibodies are typically associated with autoimmune disorders.

Observation:

  • Three patients presented with severe systemic atherosclerosis, including aortic occlusion.
  • These patients exhibited multiple cardiovascular risk factors: hypercholesterolaemia, hypertension, and a positive family history.
  • Elevated levels of anticardiolipin antibodies were detected in all three patients.

Findings:

  • High anticardiolipin antibody levels were consistently found in patients with severe atherosclerosis and hyperhomocysteinaemia.
  • The co-occurrence suggests a potential link between antiphospholipid antibodies and atherosclerotic processes.

Implications:

  • Antiphospholipid antibodies may contribute to the pathogenesis of atherosclerosis, particularly in individuals with hyperhomocysteinaemia.
  • Further research is warranted to elucidate the mechanisms by which antiphospholipid antibodies promote atherosclerosis.
  • This finding could inform novel diagnostic or therapeutic strategies for atherosclerosis.

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