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Methadone-induced myoclonus in advanced cancer
N Sarhill1, M P Davis, D Walsh
1Harry R. Horvitz Center for Palliative Medicine, Cleveland Clinic Taussig Cancer Center, Cleveland, Ohio, USA.
The American Journal of Hospice & Palliative Care
|June 16, 2001
Abstract:
Methadone is recommended as being free of some of the neuropsychological side effects noticed with morphine, which are attributed to active metabolites. A patient that received methadone for cancer-associated pain developed myoclonus as a side effect. This has rarely been reported before in the literature. The pathophysiology and management of myoclonus are discussed.