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[Effects of endothelin-1 on choroidal vessels--2. Study using indocyanine green videoangiography]
1Department of Ophthalmology, Okayama University Medical School, 2-5-1 Shikata-cho, Okayama 700-8558, Japan.
Purpose:
The effects of intravenous administration of endothelin-1(ET-1) on choroidal arteries were studied using indocyanine green videoangiography.
Methods:
The changes in caliber of the choroidal arteries in eight albino rabbits were examined using indocyanine green videoangiography with a scanning laser ophthalmoscope and an image analysis system.
Results:
Administration of 10(-9) mol/kg of ET-1 induced a significant reduction in diameter of 50.5-80.1%(median = 64.15%) 5 minutes after administration. The constriction continued for more than 60 minutes.
Conclusion:
This study demonstrates that intravenous administration of ET-1 induces long-lasting constriction of choroidal arteries. This suggests that ET-1 may participate in the regulation of choroidal artery tone.