Pathologic and laboratory correlation in microcephaly associated with prenatal cocaine exposure
A Kesrouani1, C Fallet, E Vuillard
1Obstetrics and Gynaecology Department, Maternité de l'Hôpital Robert Debré, 48 Boulevard Sérurier, 75019 Paris, France.
Early Human Development
|June 16, 2001
Abstract:
The Authors report a case where cocaine abuse during pregnancy assessed by drug analysis at various site was associated with foetal microcephaly. Foetal pathologic findings revealed anomalies in neuronal migration and in the vascular architecture in the brain. Such anomalies might be the result of prolonged exposure to cocaine in utero, aggravated by the high concentration of cocaine metabolites in the amniotic fluid over a prolonged period.


