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Related Experiment Videos

Cytokine changes after a marathon race.

D C Nieman1, D A Henson, L L Smith

  • 1Department of Health, Leisure, and Exercise Science, Appalachian State University, Boone, North Carolina 28608, USA. niemandc@appstate.edu

Journal of Applied Physiology (Bethesda, Md. : 1985)
|June 16, 2001
PubMed
Summary

Carbohydrate intake during marathon running attenuated cortisol and anti-inflammatory cytokine increases. Marathon runners experienced elevated pro- and anti-inflammatory cytokines regardless of age or gender.

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Area of Science:

  • Exercise Physiology
  • Immunology
  • Sports Nutrition

Background:

  • Marathon running induces significant physiological stress, impacting inflammatory markers.
  • Understanding the role of nutrition, gender, and age on post-race inflammation is crucial for athlete recovery.

Purpose of the Study:

  • To investigate the effects of carbohydrate (CHO) ingestion on plasma cytokine and hormone changes after marathon races.
  • To examine the influence of gender and age on these physiological responses.

Main Methods:

  • 98 marathon runners were randomized into carbohydrate (n=48) and placebo (n=50) groups.
  • Beverages were administered double-blindly during the race; blood samples analyzed for cytokines (IL-10, IL-1ra, IL-6, IL-8) and cortisol.
  • Data analyzed for differences based on CHO intake, gender, and age.

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Main Results:

  • Plasma glucose and cortisol were significantly different between groups (higher glucose, lower cortisol in CHO group).
  • All measured cytokines (IL-10, IL-1ra, IL-6, IL-8) increased post-race, with IL-10, IL-1ra, and IL-8 patterns differing between groups.
  • No significant influence of gender or age on cytokine changes was observed.

Conclusions:

  • Marathon completion leads to significant increases in pro- and anti-inflammatory cytokines, unaffected by age or gender.
  • Carbohydrate ingestion effectively attenuates post-race cortisol and anti-inflammatory cytokine (IL-10, IL-1ra) elevations.
  • Sports nutrition strategies, specifically CHO intake, play a key role in modulating exercise-induced inflammation.