Related Experiment Video

Updated: Oct 7, 2026

Assessment of Intestinal Transcytosis of Neonatal Escherichia coli Bacteremia Isolates
08:32

Assessment of Intestinal Transcytosis of Neonatal Escherichia coli Bacteremia Isolates

Published on: February 17, 2023

Endotoxin, cytokines and lipid peroxides in children with intussusception

I E Willetts1, P Kite, G R Barclay

  • 1Department of Paediatric Surgery, Leeds Teaching Hospitals NHS Trust, UK.

The British Journal of Surgery
|June 20, 2001
PubMed

Insights

Pediatric intussusception involves elevated inflammatory markers like C-reactive protein (CRP). CRP levels correlate with disease severity, aiding in clinical outcome prediction for this common surgical emergency.

Area of Science:

  • Pediatric Surgery
  • Immunology
  • Biochemistry

Background:

  • Intussusception is a frequent pediatric surgical emergency.
  • Understanding inflammatory responses is crucial for managing intussusception.

Purpose of the Study:

  • Investigate inflammatory mediators in children with acute intussusception.
  • Identify plasma markers for predicting clinical outcomes.

Main Methods:

  • Prospective data collection on clinical, radiographic, operative, and pathological details.
  • Analysis of plasma samples for malondialdehyde, CRP, IL-6, neopterin, TNF-alpha, endotoxin, and IgG/IgM antiendotoxin antibodies.
  • Comparison of acute and convalescent blood samples.

Main Results:

  • Elevated plasma levels of IL-6, neopterin, and CRP in acute intussusception compared to convalescent samples.
  • CRP identified as the most effective variable for differentiating treatment groups.
  • Increased IgM antiendotoxin core antibody (EndoCAb) concentrations in convalescent sera.

Conclusions:

  • Childhood intussusception is linked to endotoxemia and increased circulating inflammatory cytokines.
  • Plasma CRP levels at diagnosis correlate positively with disease severity.
  • CRP shows potential as a biomarker for intussusception severity.
Abstract

More Related Videos

In Vitro Apical-Out Enteroid Model of Necrotizing Enterocolitis09:11

In Vitro Apical-Out Enteroid Model of Necrotizing Enterocolitis

Published on: June 8, 2022

Chronic Salmonella Infection Induced Intestinal Fibrosis08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

Related Concept Videos

Intestinal Obstruction II: Pathophysiology01:07

Intestinal Obstruction II: Pathophysiology

Intestinal obstruction triggers a series of physiological responses, starting with gas and fluid accumulation in the bowel segment proximal to the obstruction, leading to distension. This distended intestine compresses the diaphragm, hindering lung expansion and potentially leading to reduced respiratory effort, atelectasis, and pneumonia.To overcome the blockage, the gut intensifies contractions, causing colicky abdominal pain, nausea, and vomiting, which reduces fluid and food intake and...
Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Bacterial Toxins01:12

Bacterial Toxins

Bacterial toxins are sophisticated virulence factors that enable pathogenic bacteria to interact with, invade, and damage host tissues. These toxins fall broadly into two types: protein exotoxins, which are secreted into the environment and target specific host receptors, and lipopolysaccharide endotoxins, which are structural components of the bacterial outer membrane released primarily during bacterial lysis or membrane shedding. Exotoxins generally act more selectively, binding to cell...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the goblet,...