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[Acute osteomyelitis. Clinical, radiological and bacteriological features and outcome]
J Merino Arribas1, I Carpintero Martín, M Marrero Calvo
1Sección de Escolares, Servicio de Pediatría, Hospital General Yagüe, Burgos. jmmerino@hgy.es
Insights
Neonatal acute osteomyelitis presents differently than in older children, with distinct radiological and anatomical features. Early diagnosis and treatment are crucial for favorable outcomes in both age groups.
Area of Science:
- Pediatric infectious diseases
- Musculoskeletal infections
- Neonatal care
Background:
- Acute osteomyelitis is a bone infection that can affect children of all ages.
- Distinguishing features between neonatal and older pediatric cases are not well-defined.
Purpose of the Study:
- To compare clinical, radiological, bacteriological features, and outcomes of neonatal acute osteomyelitis with those in older children.
Main Methods:
- Retrospective analysis of 45 patients under 15 years with acute osteomyelitis.
- Patients divided into two groups: neonates (<= 28 days) and older children (> 28 days).
- Statistical analysis using Chi-square and Student's t-tests.
Main Results:
- Neonates (Group 1) showed higher rates of epiphyseal involvement, arthritis, and humerus affection, with predominant osteolysis and periosteal reaction.
- Older children (Group 2) more frequently had metaphyseal and tibial involvement.
- Staphylococcus aureus was the most common pathogen; imaging techniques like bone scintigraphy and MRI demonstrated high sensitivity.
Conclusions:
- Acute osteomyelitis exhibits distinct clinical and radiological characteristics in neonates versus older children.
- Advanced imaging modalities are highly sensitive for diagnosis.
- Bacteriological confirmation was achieved in 50% of cases, with Staphylococcus aureus being prevalent.
Objective:
To compare the clinical, radiological, bacteriological features and outcome of neonatal patients with acute osteomyelitis aged (28 days with those of children aged <= 28 days of age.
Patients And Methods:
A retrospective analysis was performed. The clinical histories of patients aged less than 15 years diagnosed with acute osteomyelitis in a tertiary care hospital were reviewed. Acute osteomyelitis was defined as the association between at least two of the following variables: a) positive blood or biopsy culture; b) purulent bone aspiration; c) clinical features compatible with a diagnosis of acute osteomyelitis; d) radiological features suggestive of acute osteomyelitis, and e) favorable outcome after antibiotic treatment. The patients were divided into two groups: group 1: neonatal patients (aged (28 days) and group 2: children aged <= 28 days. Statistical analysis was performed by the Chi-square test and Student's t-test for categorized and numeric variables, respectively.
Results:
Between 1977 and 1999, 45 children aged less than 15 years old were diagnosed with acute osteomyelitis. Of these, 17 patients were neonates (group 1) and 28 patients were aged more than 28 days old (group 2). The male:female ratio was 1.1:1 in group 1 and 3:1 in group 2. The mean age was 17.7 +/- 7.5 days in group 1 and 7.2 +/- 4.3 years in group 2. Metaphysis and tibia were more commonly affected in group 2 (p < 0.05). Epiphysis, arthritis and humerus were more frequently affected in group 1 (p < 0.05). Osteolysis and periosteal reaction predominated in group 1 (p < 0.05). 99mTc Bone scintigraphy and magnetic resonance imaging showed pathological findings in all patients. Blood culture revealed Staphylococcus aureus in 46 % of the patients. Blood and biopsy material cultures were positive in 46 % and 75 %, respectively. Of the 45 patients, outcome was favorable in 37 (82.2 %).
Conclusion:
Acute osteomyelitis showed different characteristics in the neonatal and postnatal periods. Bone scintigraphy and magnetic resonance showed high sensitivity. Bacteriology was positive in 50 % of patients.
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