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[Sjögren's syndrome and multiple sclerosis].
C Iñiguez1, J Mauri, M Medrano
1Neurología. Hospital Clínico Universitario. Zaragoza. ciniguezm@nacom.es
Neurologia (Barcelona, Spain)
|June 20, 2001
Summary
Sjögren's syndrome can mimic multiple sclerosis (MS) symptoms, including neurological deficits and brain lesions. Early consideration of SS is crucial for accurate diagnosis in patients presenting with MS-like conditions.
Area of Science:
- Neurology
- Rheumatology
- Immunology
Background:
- Multiple sclerosis (MS) is a CNS autoimmune disease.
- Rheumatic diseases like Sjögren's syndrome (SS) can mimic MS.
Observation:
- Two patients with MS presented with xerophthalmia, xerostomia, and positive Ro antibodies.
- Both patients exhibited neurological symptoms and brain lesions on MRI consistent with MS.
Findings:
- Patients fulfilled diagnostic criteria for SS, despite initial MS diagnosis.
- Elevated autoantibodies (ANA, Anti-SSA) were noted in follow-up studies.
Implications:
- SS should be considered in the differential diagnosis of MS.
- Neurological manifestations of SS can closely resemble MS, necessitating thorough autoimmune workup.