Related Experiment Video

Updated: May 12, 2026

A Simple Approach to Induce Experimental Autoimmune Neuritis in C57BL/6 Mice for Functional and Neuropathological Assessments
07:30

A Simple Approach to Induce Experimental Autoimmune Neuritis in C57BL/6 Mice for Functional and Neuropathological Assessments

Published on: November 9, 2017

9.3K

[Relation between COVID-19 and Guillain-Barré syndrome in adults. Systematic review]

L M Trujillo Gittermann1,2, S N Valenzuela Feris3, A von Oetinger Giacoman4,5

  • 1Escuela de Kinesiología, Facultad de Ciencias de la Salud, Universidad de las Américas, Santiago, Chile.

Neurologia (Barcelona, Spain)
|April 15, 2024
PubMed

Insights

A strong association exists between COVID-19 and Guillain-Barré syndrome (GBS). This review found that COVID-19-associated GBS cases often present with more severe symptoms.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Epidemiology

Context:

  • Growing number of reported cases linking COVID-19 infection with Guillain-Barré syndrome (GBS).
  • Limited comprehensive understanding of the clinical implications and presentation of this association in adults.

Purpose:

  • To systematically review and analyze existing evidence on the association between COVID-19 and Guillain-Barré syndrome in the adult population.
  • To elucidate the characteristics and severity of GBS in the context of SARS-CoV-2 infection.

Summary:

  • A systematic review of 47 identified studies, with final analysis of 24 articles involving 30 patients, was conducted.
  • The review identified a significant association between COVID-19 and Guillain-Barré syndrome.
  • Findings indicate that COVID-19-associated GBS may present with increased symptom severity compared to non-COVID-19 related GBS.

Impact:

  • Provides crucial insights into the neurological complications of COVID-19.
  • Highlights the need for increased clinical vigilance for GBS in COVID-19 patients.
  • Informs diagnostic and management strategies for patients presenting with GBS during the pandemic.
Abstract

Keywords:
COVID-19Demyelinating diseasesGuillain-Barré syndromeNeuropathiesSARS-CoV-2

More Related Videos

Author Spotlight: Unveiling the Pathway Linking Obesity to Autoimmune Inflammation in Multiple Sclerosis08:17

Author Spotlight: Unveiling the Pathway Linking Obesity to Autoimmune Inflammation in Multiple Sclerosis

Published on: February 23, 2024

4.1K
Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment08:36

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

Published on: April 19, 2024

505

Related Concept Videos

Encephalitis ll: Pathophysiology01:26

Encephalitis ll: Pathophysiology

Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
Myasthenia Gravis ll: Pathophysiology01:22

Myasthenia Gravis ll: Pathophysiology

The disease process of myasthenia gravis begins at the neuromuscular junction, where antibodies attack key proteins needed for muscle activation. This immune reaction weakens signal transmission, leading to the characteristic muscle fatigue and weakness that define the condition.Immune-Mediated DamageIn most individuals, antibodies target acetylcholine receptors (AChRs) on the postsynaptic membrane of muscle cells. By blocking acetylcholine binding, these antibodies prevent the nerve signal...
Secondary Spinal Cord Injury llI: Pathophysiology01:25

Secondary Spinal Cord Injury llI: Pathophysiology

Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...