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Relation between COVID-19 and Guillain-Barré syndrome in adults. Systematic review

L M Trujillo Gittermann1, S N Valenzuela Feris2, A von Oetinger Giacoman3

  • 1Escuela de Kinesiología, Facultad de Ciencias de la Salud, Universidad de las Américas, Santiago, Chile; Escuela de Kinesiología, Facultad de Salud y Odontología, Universidad Diego Portales, Santiago, Chile.

Neurologia
|September 8, 2020
PubMed

Insights

A strong association exists between COVID-19 and Guillain-Barré syndrome in adults. This review found COVID-19-associated Guillain-Barré syndrome presents with greater symptom severity.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Public Health

Background:

  • Growing reports link COVID-19 infection to Guillain-Barré syndrome.
  • Limited data exists on the implications and characteristics of this association.
  • This review focuses on the adult population.

Purpose of the Study:

  • To systematically review and analyze the evidence on Guillain-Barré syndrome associated with COVID-19 in adults.
  • To consolidate current knowledge regarding this neurological complication.

Main Methods:

  • Systematic review methodology employed.
  • Searches conducted across major scientific databases including PubMed, Cochrane, Science Direct, Medline, and the WHO COVID-19 database.
  • Covidence platform utilized for study analysis.

Main Results:

  • Initial search identified 47 studies.
  • Final analysis included 24 articles, encompassing data from 30 patients.
  • A significant association between COVID-19 and Guillain-Barré syndrome was confirmed.

Conclusions:

  • A robust link between COVID-19 and Guillain-Barré syndrome is established.
  • COVID-19-associated Guillain-Barré syndrome cases exhibit increased symptom severity compared to typical presentations.
  • Further research is warranted to fully understand the nuances of this association.
Abstract

Keywords:
COVID-19Demyelinating diseasesEnfermedades desmielinizantesGuillain-BarréGuillain-Barré syndromeNeuropathiesNeuropatíasSARS-CoV-2

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