Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Nuclear export of mRNA.

D Zenklusen¹, F Stutz

¹Institute of Microbiology, Centre Hospitalier Universitaire Vaudois, 44, rue du Bugnon, 1011, Lausanne, Switzerland.

|June 20, 2001

Summary

Messenger RNA (mRNA) export from the nucleus requires coordinated processing into messenger ribonucleoprotein complexes (mRNPs). This review summarizes yeast and mammalian factors involved in mRNA export through nuclear pore complexes (NPCs).

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

mRNA export: travelling with DEAD box proteins.

Current biology : CB·2001

Same author

The yeast hnRNP-Like proteins Yra1p and Yra2p participate in mRNA export through interaction with Mex67p.

Molecular and cellular biology·2001

Same author

Yeast Ran-binding protein 1 (Yrb1) shuttles between the nucleus and cytoplasm and is exported from the nucleus via a CRM1 (XPO1)-dependent pathway.

Molecular and cellular biology·2000

Same author

REF, an evolutionary conserved family of hnRNP-like proteins, interacts with TAP/Mex67p and participates in mRNA nuclear export.

RNA (New York, N.Y.)·2000

Same author

Positive and negative mutant selection in the human histone hairpin-binding protein using the yeast three-hybrid system.

Nucleic acids research·2000

Same author

The RNA export factor Gle1p is located on the cytoplasmic fibrils of the NPC and physically interacts with the FG-nucleoporin Rip1p, the DEAD-box protein Rat8p/Dbp5p and a new protein Ymr 255p.

The EMBO journal·1999

Area of Science:

Molecular Biology
Cell Biology
Genetics

Background:

Messenger RNA (mRNA) export from the nucleus is a critical step in gene expression.
This process involves the formation of export-competent messenger ribonucleoprotein complexes (mRNPs).
Numerous factors facilitate mRNA translocation through nuclear pore complexes (NPCs).

Purpose of the Study:

To summarize recent advancements in understanding mRNA export mechanisms.
To review the characterization of factors involved in yeast and mammalian mRNA export.
To highlight the importance of functional characterization and interaction networks.

Main Methods:

Genetic approaches in yeast to identify export factors.
Identification of functional homologues in metazoan systems.
Functional characterization of identified components.

Main Results:

Key factors involved in mRNA processing and mRNP formation have been identified.
Mechanisms of mRNP translocation through NPCs are being elucidated.
Homologues of yeast export factors exist in higher eukaryotes.

Conclusions:

Understanding mRNA export requires detailed functional analysis of involved factors.
Establishing a comprehensive network of molecular interactions is crucial.
Progress in yeast and mammalian systems provides insights into conserved export pathways.

Related Experiment Videos