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Infusion of the metabotropic receptor agonist, DCG-IV, into the main olfactory bulb induces olfactory preference
J D Rumsey1, A Darby-King, C W Harley
1Division of Basic Sciences, Faculty of Medicine, Memorial University of Newfoundland, Health Sciences Centre, St. John's, Newfoundland, Canada A1B 3V6.
Abstract:
DCG-IV, a type 2 metabotropic glutamate receptor (mGluR2) agonist, was infused into the main olfactory bulb of 1-week-old pups exposed to peppermint odor. A preference for peppermint was demonstrated 24 h later. The data support the proposal that disinhibition at dendrodendritic synapses between granule cells and mitral cells is a critical component of olfactory memory formation in the rat pup olfactory bulb as well as in the accessory olfactory bulb of adult rodents.
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