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Comparison of Botulinum Toxin Versus Steroid Injection for Recurrent Laryngeal Contact Granuloma
Shufang Zhang1, Jie Shan1, Qian Nie1
1Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Bengbu Medical University, Bengbu, 233000, China.
Objectives:
To compare the efficacy of botulinum toxin injection versus steroid injection in the treatment of patients with recurrent laryngeal contact granuloma.
Methods:
A retrospective analysis was conducted on clinical data from 44 patients with recurrent laryngeal contact granuloma who received either botulinum toxin injection or steroid injection between August 2021 and April 2026. Patients were divided into a botulinum toxin injection group and a steroid injection group. The cure rate, recurrence rate, and time to cure were compared between the two groups to determine the optimal treatment for patients with recurrent lesions.
Results:
In patients with recurrent granulomas, the botulinum toxin injection group demonstrated a higher cure rate (90%) and a lower recurrence rate (0%) compared with the steroid injection group (cure rate: 76.47%; recurrence rate: 11.54%), although the differences were not statistically significant (P > 0.05). The time to cure in the steroid injection group was significantly longer than that in the botulinum toxin injection group (P < 0.01).
Conclusion:
In patients with recurrent laryngeal contact granuloma, botulinum toxin injection was associated with a shorter time to cure compared with steroid injection. Botulinum toxin injection is an effective treatment for recurrent granulomas.