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[Para-aortic lymph node involvement in gastric adenocarcinoma]
G De Manzoni1, A Di Leo, G Borzellino
1Divisione clinicizzata di chirurgia generale, ospedale civile maggiore, piazzale A. Stefani 1, 37126 Vérone, Italie.
Annales De Chirurgie
|June 21, 2001
Summary
Superextended lymphadenectomy (D4) is significant for advanced gastric cancer. Para-aortic lymph node (N4) metastasis occurs in 18.2% of patients, particularly those with proximal tumors.
Area of Science:
- Surgical Oncology
- Gastrointestinal Oncology
- Cancer Metastasis
Context:
- Gastric cancer management remains a significant global health challenge.
- Advanced stages often involve lymph node metastasis, impacting prognosis.
- The role of extensive lymphadenectomy, specifically D4, requires further elucidation.
Purpose:
- To evaluate the significance of superextended lymphadenectomy (D4) in gastric cancer.
- To determine the incidence of para-aortic lymph node (N4) metastases.
- To analyze the relationship between N4 metastasis and tumor location.
Summary:
- A study of 110 gastric cancer patients undergoing D4 lymphadenectomy found 18.2% had para-aortic lymph node (N4) involvement.
- N4 metastasis was most frequent in proximal third tumors (33%).
- Postoperative mortality was 2.7% and morbidity 29.1%.
Impact:
- Findings suggest D4 lymphadenectomy is crucial for curative treatment of advanced gastric cancer.
- Highlights the importance of considering D4, especially for proximal gastric tumors.
- Contributes to optimizing surgical strategies for improved gastric cancer outcomes.