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Aryl rings are part of the darpone pharmacophore
1Universität Hamburg, Institut für Pharmazie, Bundesstrasse 45, D-20146 Hamburg, Germany.
Archiv Der Pharmazie
|June 21, 2001
Abstract:
In order to investigate structure-activity relationships in the antiproliferative darpone series, the derivatives 8a and 8b lacking the aryl substituents in either 2- or 4-position were synthesized and evaluated for cancer cell growth inhibition. Since both 8a and 8b were devoid of noteworthy antiproliferative activity, both aryl substituents can be considered as part of the darpone pharmacophore.